A DNA fragment of 5000bp needs to be isolated from $E.coli$ (genome size $4\times10^3 kb$) genomic library.

The minimum number of independent recombinant clones required to represent this fragment in genomic library are

1. $16\times10^2$
2. $12\times10^2$
3. $8\times10^2$
4. $1.25\times10^2$

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