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Which one of the following statements about $Agrobacterium \;Ti\; plasmid$ is $CORRECT$?

  1. $Vir$ genes are located within the $T-DNA$ segment
  2. Phytohormone biosynthesis genes are located outside the $T-DNA$ segment
  3. Opine catabolism genes are located within the $T-DNA$ segment
  4. Opine biosynthesis genes are located within the $T-DNA$ segment
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