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Which of the following statements are $CORRECT$ when a protein sequence database is searched using the $BLAST$ algorithm?

  1. A larger E-value indicates higher sequence similarity
  2. E-value $<10^{-10}$ indicates sequence homology
  3. A higher BLAST score indicates higher sequence similarity
  4. E-value $>10^{10}$ indicates sequence homology
  1. $P, Q$ and $R$ only
  2. $Q$ and $R$ only
  3. $P, R$ and $S$ only
  4. $P$ and $S$ only
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