Which of the following statements are $CORRECT$ when a protein sequence database is searched using the $BLAST$ algorithm?
- A larger E-value indicates higher sequence similarity
- E-value $<10^{-10}$ indicates sequence homology
- A higher BLAST score indicates higher sequence similarity
- E-value $>10^{10}$ indicates sequence homology
- $P, Q$ and $R$ only
- $Q$ and $R$ only
- $P, R$ and $S$ only
- $P$ and $S$ only