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​​​​An enzyme immobilised in a porous spherical pellet, catalyses a strongly mass-transfer limited first-order reaction. The effectiveness factor for the immobilised enzyme reaction increases with the

  1. decrease in the size of the pellet
  2. increase in the pore diffusivity within the pellet
  3. decrease in the enzyme turnover number
  4. increase in the enzyme concentration within the pellet

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