Which of the following statements are $\text{CORRECT}$ for an enzyme entrapped in a spherical particle?

1. Effectiveness factor is ratio of the reaction rate with diffusion-limitation to the reaction rate without diffusion-limitation
2. Internal diffusion is rate-limiting at low values of Thiele modulus
3. Effectiveness factor increases with decrease in Thiele modulus
4. Internal diffusion-limitation can be reduced by decreasing the size of the particle