Which of the following statements are $\text{CORRECT}$ for an enzyme entrapped in a spherical particle?
- Effectiveness factor is ratio of the reaction rate with diffusion-limitation to the reaction rate without diffusion-limitation
- Internal diffusion is rate-limiting at low values of Thiele modulus
- Effectiveness factor increases with decrease in Thiele modulus
- Internal diffusion-limitation can be reduced by decreasing the size of the particle