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An enzyme-catalyzed reaction is found to have $\Delta \mathrm{G}=-100 \mathrm{~kJ} \mathrm{~mol}^{-1}$. Which of the following statements about this reaction is/are true?

  1. The rate of the reaction cannot be predicted
  2. The rate of the reaction is high
  3. The rate of the reaction is low
  4. The reaction is irreversible

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