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Which one of the following statements is $\text{INCORRECT}$ about hybridoma production?

  1. Hybridoma cella can use hypoxanthine and thymidine
  2. $\text{DNA}$ synthesis in myeloma cells is blocked by aminopterin
  3. Hybridoma cells are made to produce polyclonal antibodies
  4. Polyethylene glycol is used to fuse myeloma cells to $B$-cells
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