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Which of the following statements are $CORRECT$?

  1.  Viruses can play a role in causing human cancer.
  1. A tumor suppressor gene can be turned off without any change in its $DNA$ sequence.
  1. Alteration in $miRNA$ expression levels contributes to the development of cancer.
  1. $P$ and $Q$ only
  2. $Q$ and $R$ only
  3. $P$ and $R$ only
  4. $P$, $Q$ and $R$
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