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Which of the following cytokines are endogenous pylogens?

  1. Tumor necrosis factor-$\alpha$
  2. Interleukin-$1$
  3. Transforming growth factor-$\beta$
  4. Interleukin-$10$
  1. P and Q only
  2. P and R only
  3. R and S only
  4. Q and S only
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