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Which one of the following statements is true with regard to processing and presentation ofprotein antigens?

  1. In the class II MHC pathway. protein antigens in the cytosol are processed byproteasomes
  2. In the class I MHC pathway. extracellular protein antigens are endoc'osed into vesiclesand processed
  3. In the class I MHC' pathway. transporter associated antigen processing (TAP) protein isrequired for translocating processed peptides generated in the cytosol
  4. Invariant chain in endoplasmic reticulum is involved in transport of peptides and loadingof class I MHC
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