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GATE2018-32

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Which one of the combinations of the following statements is true about antibody structure?

  1. Limited proteolysis of rabbit IgG with the enzyme pepsin generates two antigen-binding regions (Fab) and an Fc fragment.
  2. Limited proteolysis of rabbit IgG with the enzyme papain generates a single bivalent antigen-binding region F(ab')$_2$ and peptide fragments.
  3. The Fc fragment of IgG can self-associate and crystallize into a lattice.
  4. The F(ab')$_2$ fragment of IgG is composed of both light and heavy chains.
  1. P and Q only
  2. P and R only
  3. R and S only
  4. Q and S only
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