# GATE2016-28

A DNA sequence, $\textrm{5’ -ATGGACGTGCTTCCCAAAGCATCGGGC- 3’}$, is mutated to obtain

1. $\textrm{5'-ATGGACGTGCTTC}\textbf{a}\textrm{CAAAGCATCGGGC- 3'}$
2. $\textrm{5'-ATGGACGTGCTTCCC}\textbf{g}\text{AAAGCATCGGGC-3'}$
3. $\textrm{5'-ATGGACGTGCTTCC- AAAGCATCGGGC- 3'}$
4. $\textrm{5'-ATGGACGTGCTTCCCAA}\textbf{t}\textrm{GCATCGGGC- 3'}$
5. $\textrm{5'-ATGGACG}\textbf{a}\textrm{GCTTCCCAAAGCATCGGGC- 3'}$

[Point mutations are showm in the lower case or $’-’$ Within the sequences]

Which of the above mutant sequences DO NOT have frame-shift?

1. P, Q and S
2. P, S and T
3. Q, R and S
4. Q, S and T
in Others
edited