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The enzymes involved in ubiquitinylation of cell-cycle proteins are

  1. $\text{E}_{1}$ and $\text{E}_{2}$ Only
  2. $\text{E}_{1}$ and $\text{E}_{3}$ Only
  3. $\text{E}_{1}$ and $\text{E}_{4}$ Only
  4. $\text{E}_{1}$, $\text{E}_{2}$ and $\text{E}_{3}$
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